They discover a molecule that improves adaptation to exercise

A team from the University of Oviedo, integrated into the Institute of Health Research of the Principality of Asturias (ISPA), has led an international study that reveals how skeletal muscle sends signals to the rest of the organism when we train. The key is in small molecules called Micrrornathat travel through the blood and act as messengers between fabrics.

The research highlights the role of Micrrorna MIR-29A-3Pwhich is essential for the body to adapt to the exercise of force and Keep muscle power. According to the authors, these findings help better understand how training – especially strength – influences health and energy metabolism.

The Micrrorna They are not new for science: His discovery was recognized with the Nobel Prize in Medicine in 2024. These molecules have the ability to regulate the expression of genes, not only in the cells that produce them, but also in others further those that reach the blood.

To check their function, the researchers trained two groups of mice for a month: Some practiced resistancerunning on tape, and other strength, uploading a ladder with small pesos. The analysis revealed eleven Micrrorna whose blood levels varied with the exercise of force, being the MIR-29A-3P The most decisive.

The results indicate that this molecular messenger intervenes in communication between muscle and liver During exercise, influencing how both tissues manage energy.

“We confirm that the MIR-29A-3P It is key in adaptation to strength training, at least in animal models and cell cultures. The next step is to confirm whether these results are met in humans “explains the doctor Fernández SanjurjoProfessor of Functional Biology at the University of Oviedo and first signer of the study.

The study is the result of an international collaboration between the University of Oviedo, which has led this work, the Karolinska Institute (Sweden), the University of Texas Southwestern (USA (UU.) And the University of Barcelona.