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A multidisciplinary team of experts from various universities and Spanish research centers has developed hydrogels from tuna collagen that have shown potential in the localized drug release against him breast cancerwhich opens the door to more precise and localized therapies against disease that improve quality of life of the patients.
As explained by the Polytechnic University of Madrid (UPM)participant in the study through a researcher, these hydrogels are biocompatible and biodegradableIn addition to having a structure and consistency that allow them to be injected. All this makes them good candidates for encapsulate drugs that can be administered precisely where they need to be released to controlled and precise actions.
The work, published in the European Journal of Pharmaceutics and Biopharmaceuticshas had the collaboration of the Polytechnic University of Madrid (UPM)the University of Castilla-La Manchathe University of Vigohe CSIC Marine Research Institutehe San Carlos Health Research Institutethe Jiménez Díaz Foundation and the ALBA synchrotron to evaluate the possible medical application of the hydrogels.
Promising results in the laboratory
The specialist group, which includes experts in biomaterials, chemistry, physics, cell biology and experimental oncologyhas worked with two compounds aimed at the treatment of breast cancerhe BET JQ1 inhibitor and the PROTAC MZ1and has been simulated in the laboratory using rheology an injection with the hydrogel. Thus, you have verified that the material flows and that, once deposited, stabilizes again in the body.
In studies in vitro using three cell lines of breast cancer, encapsulated drugs in the hydrogel they remained assetsthey reduced the viability and cell migrationand promoted the apoptosiswith results similar to the compounds in the free case. The formulation also alleviates the drawbacks of low solubility and potential systemic toxicity, Europa Press reports.
Towards more precise and sustainable therapies
This work establishes scientific bases for the investigation of more precise and localized therapies against cancer, with the option of reducing side effects and improve the quality of life of the patients.
Furthermore, the collagen produced from the by-products of the fishing industry contributes to the use of natural resources that would otherwise be marginalized and underutilized, in line with the techniques of sustainability and circular economy in biomedicine.
“This work lays the foundation for further studies in 3D models and animal testing to determine the security, degradation, retention and distributionas well as the degree to which the system can be used for precision medicine and localized treatments in specific sites that can lead to other uses,” explained the researcher from the UPM Carolina Hermida.
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