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A team from the Institute of Neurosciences of the University of Barcelona (UBneuro) has discovered that early and “sustained” cognitive stimulation can help preserve brain function and memory in Alzheimer’s, even at advanced points of the pathology.
Published in iSciencethe study has been carried out with animal models and also reveals that males respond better than females to cognitive intervention to delay the onset of the disease, the UB reports in a statement this Tuesday.
The animals were subjected to repeated cognitive training throughout their lives, and brain function was evaluated with longitudinal resting fMRI, behavioral memory tests, and “exhaustive” molecular and cellular analyses.
The preservation of brain connectivity was associated with better memory performance at older ages: this, according to the researcher Guadalupe Soria“reinforces the idea that cognitive engagement early in life can have lasting protective effects on brain function,” he notes.
Regarding cognitive stimulation, the females showed higher basal levels of proteins related to synaptic function and plasticity, “suggesting greater intrinsic molecular resilience”; and the males They benefited more from cognitive training, with sustained brain connectivity and better memory performance.
The results reinforce the evidence that Alzheimer’s disease “progresses differently in men and women” and that preventive or therapeutic strategies should be adapted to address this neurodegenerative pathology.
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