Greater risk of Alzheimer and Parkinson

An international study published in ‘Science Advances‘has shown an association between digestive disorders, such as colitis, gastritis, esophagitis or intestinal functional disorders, and the development of the disease of Alzheimer’s (EA) and the disease of Parkinson (EP).

These two diseases are the two Most common neurodegenerative disorders And they affect, together, more than 400 million people worldwide. Although important genetic risk factors for EA and EP have been identified, it is believed that sporadic and latest forms are due to a complex interaction between genetic and environmental factors.

For researchers, this interaction underlines the importance of exploring various variables in different body systems to understand their contribution to the etiology of EA/EP. Therefore, scientists have carried out this study among 500,000 people with the aim of identifying endocrine, nutritional, metabolic and digestive disorders with possible causal or temporal associations with the risk of Alzheimer’s disease and Parkinson’s disease before diagnosis.

“An international team of researchers from different American, British, Spanish and Brazilian research centers have analyzed whether different intestinal diseases (gastritis, esophagitis, bacterial intestinal infections, gastroenteritis and others) contribute to a greater incidence of cerebral neurodegenerative disorders such as Alzheimer’s and Parkinson diseases. Clinical records available in three biobancos databases, “the senior researcher of the gene therapy program in neurodegenerative diseases at the Center for Applied Medical Research (CIMA) of the University of Navarra, José Luis Lanciego.

The findings show that several disorders were associated with a Greater risk of Alzheimer and Parkinson Before diagnosis, with variations in the strength and moment of associations between the different conditions.

“These data corroborate existing evidence about the so-called Intestin-Cerebro axis, so that it is considered important to pay attention to these intestine pathologies in order to monitor patients and try to make an early diagnosis of brain neurodegenerative diseases,” said launching.

Polygenic risk scores reveal a lower genetic predisposition to EA/EP in people with concurrent disorders. In addition, the proteomic profile of EA/EP cases was influenced by common disorders of the Intestine-corebro axis.

“He Digestive system is often considered “the second brain”, since it has numerous neurons in its submucose layer. “It is connected to the brain bidirectionally through the vagus nerve. There are numerous evidence that demonstrates a main role of the intestinal microbiota and its alterations (known as intestinal disbiosis) when it comes to triggering cerebral neurodegenerative diseases,” said launching.

Finally, multimodal prediction models exceed the unique modality paradigms in disease classification. This effort highlights the interaction between the factors involved in the Intestin-Cerebro axis and the development of the EA/EP, which opens new paths for therapeutic orientation and early diagnosis.