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The biological changes associated with the disease Parkinson’s (EP) can appear up to 12 years before diagnosis clinical, according to the Chronos-PD program of Grifols.
The results, published in the journal ‘medRxic‘, represent a finding “with important implications for early detection and intervention,” the multinational reported this Tuesday in a statement.
Chronos-PD is a platform promoted by Alkahest (a subsidiary of Grifols) and designed to identify the first signs of PD years before clinical diagnosis.
More than 2,600 samples
The study, funded by the Michael J. Fox Foundationhas analyzed more than 2,600 longitudinal plasma samples from Parkinson’s cases and “rigorously matched” controls, and has measured more than 25,000 types of proteins using 4 complementary proteomic platforms.
Samples have been used that cover a period from 12 years before the diagnosis of PD to 9 years later, which allows follow the evolution of different plasma proteins over time in people with the disease and could help establish an early warning system for the onset of the disease.
Results
Researchers have confirmed previously discovered PD biomarkers and have identified reproducible biomarkers of the diseasevalidated in up to 5 independent cohorts.
The Chief Scientific Officer of Grifols, Jörg Schüttrumpf, has highlighted that the new proof-of-concept data provides “additional information” about the biology and progression of PD, years before its clinical detection, and also validates the Chronos platform for possible applications beyond Parkinson’s.
“Going back in time to look for the early signs of the disease can help speed up and ultimately addevelop new diagnostics and modifying treatments“of the disease, he added.
The data will be presented through 13 posters and presentations at the International Conference on Alzheimer’s and Parkinson’s Diseaseswhich takes place until this Saturday in Copenhagen (Denmark).
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